Making an impression with his composed demeanour, combined with the lazy elegance of a southpaw, Padikkal stroked a fine 65 off 103 deliveries, an innings studded with 10 four and a six.
With a commanding 3-1 lead already secured, India aims to clinch victory at Dharamshala to make the scoreline 4-1, with 12 World Test Championship points still at stake.
From leading the table with four wins on the trot, the Virat Kohli-led team has slipped to third spot at the halfway stage after suffering two defeats from their last three matches.
Padikkal smashed an unbeaten 101 off 52 balls in an opening stand of 181 with Kohli as RCB registered an emphatic 10-wicket victory over Rajasthan Royals
I thought it was an exceptional innings. He played really, really well. He played the shots that he knew he could play and he kind of anticipated some of the deliveries that were going to be bowled with the fields set.
Having put up a decent performance in the first game, RCB will be strengthened further when the immensely talented Devdutt Padikkal makes the team after his recovery from COVID-19.
While Padikkal smashed four consecutive List A hundreds to become the first Indian to achieve the feat, is the leading run-scorer of the tournament with 673 runs, Shaw is not far behind with 589 runs in his kitty.
Karnataka rode on skipper Ravikumar Samarth's knock of 192 off 158 balls and a stroke-filled 101 by Padikkal (off 119 balls) to post an imposing 338/3 and then bundled out the opposition for 258