Fernandes opened the scoring for United in the ninth minute but Lorenzo Pellegrino levelled with a penalty and Edin Dzeko put Roma ahead in the 34th, DPA reported.
Marcus Rashford's fine goal and a late Bruno Fernandes penalty in Spain last week put the Red Devils in control of the quarter-final tie heading into Thursday's reverse fixture at an empty Old Trafford.
Edinson Cavani has been suspended for three games, fined £100,000 and must complete face-to-face education after admitting a charge for a breach of FA Rule E3 in relation to a social media post on Sunday 29 November 2020