It was a surprise win for the actor as many expected the Academy to honour late star Chadwick Boseman for his performance in "Ma Rainey's Black Bottom".
"When you are working for years, the good plays and films make you go around examining life. This one made me think about my past, my parents and particularly the sweet sadness of it all," said Hopkins.
"The Father" is in contention at the Oscars in the categories of Best Film, Best Actor (for Anthony Hopkins), Best Supporting Actress (Olivia Colman), Best Adapted Screenplay, Best Editing and Best Production Design.
