The president had argued that the US needs to save and protect jobs for its domestic work force at a time when millions of them lost their jobs due to the coronavirus pandemic.
The announcement came after White House adviser Hope Hicks, one of Trump's closest aide, was confirmed to have tested positive for the virus on Thursday.
Trump did not say how long he was planning to be in isolation -- he is regularly tested for the potentially deadly virus but the tests can yield false negative results.