The challenge for Everton at Anfield became significantly tougher as defender Ashley Young received his marching orders in the 37th minute, with two yellow cards issued for fouls on Liverpool winger Luis Diaz.
Arsenal were 3-0 up before Brighton pulled a goal back, with Bukayo Saka opening the scoring in the second minute and Martin Odegaard scoring a second in the 39th minute, on Saturday, reports Xinhua news agency.
The 32-year-old Argentinian will bring an end to a record-breaking decade at the club after Saturday's Champions League final against Chelsea in Porto.
In a low-key Premier League encounter, the result was settled by a mistake from goalkeeper Leno when he allowed Richarlison's cross through his legs and diverted it into the net, DPA reported.
Two late goals earned Pep Guardiola's side a place in the last four, with Ilkay Gundogan heading City ahead in the 84th minute before Kevin de Bruyne scored his side's second in the last minute on Saturday
Everton's search for a new home to replace its outdated Goodison Park stadium started 25 years ago. Club officials said the widely supported plan would see a 52,888 stadium at Bramley-Moore Dock
It was an evening to forget for two of the league's supposed title contenders on Tuesday, with Chelsea's 2-1 loss at Wolverhampton followed by Manchester City's 1-1 draw at home to West Bromwich Albion