John Stones capitalized on a clever corner routine orchestrated by Kevin De Bruyne to secure a first-half lead for City, while Alexis Mac Allister's penalty in the second half resulted in both teams earning a point each.
Man City has now secured a Premier League double over rivals Man Utd for the sixth time, with half of these achieved under Guardiola (also in 2018/19 and 2021/22).
Virgil van Dijk, Cody Gakpo, Luis Diaz, and Harvey Elliott's goals further solidified Liverpool's lead at the top of the table, extending their advantage to four points over second-place Manchester City
Sean Longstaff provided Newcastle with the lead twice in the first half, but Luton responded on both occasions, first with Gabriel Osho and later with Ross Barkley.
Despite trailing 1-0 at halftime due to Neal Maupay's goal, Spurs made a blazing start to the second half, scoring three quickfire goals to overturn the deficit and secure a crucial victory.
On the 89th minute, Forest substitute Taiwo Awoniyi scored a goal, but Arsenal maintained their lead, securing consecutive victories as they head into a crucial clash with Liverpool at Emirates Stadium on Sunday.
Newcastle's victory on Tuesday night halted their four-game losing streak in the Premier League and handed Unai Emery's side their first home defeat of the season.
At halftime, the teams were tied after Erling Haaland converted a penalty and Manuel Akanji scored with a header, while Thiago Silva and Raheem Sterling also found the back of the net.
