Israel warns of “prolonged campaign” in Tehran amid EU-Iran talks in Geneva

Israeli military’s chief spokesman, Brig. Gen. Effie Defrin, said the army had been told by Chief of Staff Lt. Gen. Eyal Zamir to be prepared for a “prolonged campaign” to destroy its targets, including nuclear sites, enrichment facilities and missile infrastructure.

Tel Aviv: Israel’s military said Saturday it struck an Iranian nuclear research facility overnight and killed three senior Iranian commanders in targeted attacks, while emphasizing it was preparing for the possibility that the war could turn into a lengthy campaign.

Early Saturday, smoke could be seen rising from an area near a mountain in Isfahan, where a local official said Israel had attacked the nuclear research facility in two waves. The target was two centrifuge production sites, and the attacks came on top of strikes on other centrifuge production sites elsewhere in recent days, according to an Israeli military official speaking on condition of anonymity under army guidelines to brief reporters.

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Iran confirms Israeli attack

It was the second attack on Isfahan, which was hit in the first 24 hours of the war as part of Israel’s goal to destroy the Iranian nuclear program. Akbar Salehi, Isfahan province’s deputy governor for security affairs, confirmed the Israeli strikes had caused damage to the facility but said there had been no human casualties.

Tehran renews attack on Tel Aviv

Iran launched a new wave of drones and missiles at Israel but there were no immediate reports of significant damage, and the Israeli official called it a “small barrage” that was largely intercepted by Israel’s defenses. The official said part of the reason that Iran’s overnight attack had been relatively small was that the military had been targeting its launchers, and estimates it has now taken out more than 50% of them.

“We’ve been able to take out a large amount of their launchers, creating a bottleneck — we’re making it harder for them to fire toward Israel,” he said.

“Having said all that, I want to say the Iranian regime obviously still has capabilities.” Israel’s Magen David Adom rescue service said Saturday an Iranian drone hit a two-story building in northern Israel, but there were no casualties.

IDF readies for a “prolonged campaign”

Later, the Israeli military’s chief spokesman, Brig. Gen. Effie Defrin, said the army had been told by Chief of Staff Lt. Gen. Eyal Zamir to be prepared for a “prolonged campaign” to destroy its targets, including nuclear sites, enrichment facilities and missile infrastructure.

“We are deepening our strikes night after night and we have amazing achievements,” he said. “We will continue until the threat is removed.”

EU-Iran talks in Geneva

Talks in Geneva on Friday failed to produce a breakthrough. European officials expressed hope for future discussions, and Iranian Foreign Minister Abbas Araghchi said he was open to further dialogue while emphasizing that Tehran had no interest in negotiating with the U.S. while Israel continued attacking.

“Iran is ready to consider diplomacy once again and once aggression is stopped and the aggressor is held accountable for the crimes committed,” he told reporters. No date was set for the next round of talks.

“Overnight, we deepened the strike on the nuclear site in Isfahan and in western Iran. On the screen, you can see the site where reconversion of enriched uranium takes place. This is the stage following enrichment in the process of developing a nuclear weapon. We had already… pic.twitter.com/UbWO3M8PBV

— Israel Defense Forces (@IDF) June 21, 2025

(With inputs from AP)