The French Open starts in Paris on May 28 and runs until June 11.
The 36-year-old Nadal has not competed since January at the Australian Open, where he suffered an injury to the iliopsoas muscle in his left leg.
Nadal and his team were expecting a recovery period of six to eight weeks, but the lefty has not returned to action.
In addition to his record 14 trophies at the Roland Garros, Nadal owns a 112-3 record across 18 career appearances at the major. His 112 match wins and his 97.4 per cent win-rate both stand alone as records, as does his perfect 14-0 mark in finals.
Last year in Paris, Nadal defeated Casper Ruud in a three-set championship match to win a record-breaking 22nd Grand Slam singles title — a mark Novak Djokovic has since equalled.
Nadal overcame a chronic foot injury to win both the Australian Open and Roland Garros last season. But the Spaniard has played just five tournaments since due to injury.