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Home | Health | This Immune Cell In Blood May Up Severe Covid Risk

This immune cell in blood may up severe Covid risk

Our results help increase the understanding of what causes severe Covid-19 and is an important piece of the puzzle in understanding the connection between the early, innate immune system, which includes M-MDSC

By IANS
Updated On - 04:12 PM, Wed - 27 January 21
This immune cell in blood may up severe Covid risk
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London, Jan 27 (IANS) Researchers have found that patients with severe Covid-19 have significantly elevated levels of a certain type of immune cells in their blood, called myeloid-derived suppressor cells.

In the study, published in the Journal of Clinical Investigation, the team researched one type of immune cell, monocytic myeloid-derived suppressor cells, or M-MDSC, and their potential role in Covid-19.

“Our results help increase the understanding of what causes severe Covid-19 and is an important piece of the puzzle in understanding the connection between the early, innate immune system, which includes M-MDSC, and the later, adaptive immune system, which includes T cells,” said researcher Anna Smed Sorensen from Karolinska Institutet.

T cells are part of the immune system and play an important part in the body’s protection against viral infections such as Covid-19. M-MDSCs have been shown to increase in other inflammatory conditions, and their suppressive effect on T cell activity has been established.

The role of M-MDSC in respiratory infections, however, is largely unknown. Since low levels of T cells are a hallmark of Covid-19, it is of interest to understand the role of M-MDSCs in this disease.

The study consisted of 147 patients with mild to fatal Covid-19 who were sampled repeatedly from blood and the respiratory tract. These were then compared with patients with influenza and healthy individuals.

The results showed that patients with severe Covid-19 have significantly elevated levels of M-MDSCs in blood compared with milder cases and healthy individuals.

Covid-19 patients had fewer T cells in blood than healthy subjects, and they showed signs of impaired function.

The analysis also showed that the levels of M-MDSCs early in the course of disease seemed to reflect subsequent disease severity.

“There is also a strong clinical connection, as you could potentially use the results to find new biomarkers for severe illness,” Sorensen added.

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