CCMB study unravels basis for side-effects of statins

Hyderabad: A study by Prof. Amitabha Chattopadhyay’s group at the CSIR-Centre for Cellular & Molecular Biology has unravelled the basis for side-effects of cholesterol-lowering drug statins. Statins are one of the top selling drugs worldwide and are used for lowering cholesterol in patients with high blood cholesterol. Statins have been reported to give rise to […]

Hyderabad: A study by Prof. Amitabha Chattopadhyay’s group at the CSIR-Centre for Cellular & Molecular Biology has unravelled the basis for side-effects of cholesterol-lowering drug statins.

Statins are one of the top selling drugs worldwide and are used for lowering cholesterol in patients with high blood cholesterol. Statins have been reported to give rise to severe side-effects to long-term users and the molecular basis of this is not clear.

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However, recent work from Prof. Amitabha Chattopadhyay’s group shows that statins could induce changes in the architecture of cells as well, possibly leading to the side effects. Published in Journal of Lipid Research, the study shows that statins affect actins as a result of multiple cellular signaling pathways.

“Our results constitute one of the first comprehensive reports dissecting the mechanistic basis underlying the interplay between cellular actin level and cholesterol biosynthesis, and provide a molecular basis for the reported side effects of statin treatment”, said Dr. Parijat Sarkar, who is the first author of the paper.

Prof. Chattopadhyay added, “these findings could provide vital clues in dissecting the biochemical processes that give rise to adverse effects of statins, thereby helping to develop better drugs in the future”.

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