The match was a one-sided affair largely and Djokovic won it 6-3, 6-1, 7-6(5), as per ATP. With this, Djokovic also avoided the chance of the match being carried over to Saturday.
Murray will take on Tsitsipas in a second-round clash on the Centre Court after Ruud will open the proceedings for the day against unseeded Briton Liam Broady.
Nadal is just 1-3 this season and has dropped seven of his past nine matches overall, dating to a fourth-round loss to Frances Tiafoe in the US Open's fourth round last September