Weight-loss surgeries may weaken bone health, suggests study

Boston: Researchers from the Harvard Medical School in Boston, Massachusetts claims that common weight-loss surgeries for adolescents with obesity called sleeve gastrectomy may lead to harmful effects on bones.

According to the study, while teenagers may opt for popular weight-loss surgeries, they may know that the common side-effect of the same may damage bone health severely.

Lead investigator of the study, Miriam A. Bredella, M.D., professor of radiology at Harvard Medical School in Boston, Massachusetts, and vice-chair of the Department of Radiology at Massachusetts General Hospital in Boston said, “Childhood obesity is a major public health issue that has increased over the last 10 years, sleeve gastrectomy is the most common bariatric surgery procedure performed in children and adults.”

In a sleeve gastrectomy, approximately 75% of the stomach is removed to restrict food intake and induce weight loss. It results in a typically round stomach taking on the shape of a tube or sleeve. The number of sleeve gastrectomy procedures performed on adolescents increased 100-fold from 2005 to 2014.

“In adults, bariatric surgery can have long-term effects on bone, leading to higher fracture risk, we wanted to determine the effects of sleeve gastrectomy performed on adolescents during the crucial years when bone mass is being accrued,” Dr Bredella said.

The study examined 52 adolescents with moderate to severe obesity, 26 of whom underwent sleeve gastrectomy. The other 26 were in the control group. The mean age was 17.5 years, and the mean body mass index (BMI) was 45. BMI of 30 or above was considered obese. Thirty-eight of the study participants were girls.

Before and 12 months after sleeve gastrectomy (or no surgery), the patients underwent quantitative CT of the lumbar spine, to quantify volumetric bone mineral density. Quantitative CT is considered a highly accurate technique for detecting changes in volumetric bone mineral density after extreme weight loss.

Recent studies have shown that bone marrow fat responds to changes in nutrition and may serve as a biomarker for bone quality. Therefore, patients underwent proton MR spectroscopy to quantify bone marrow fat of the lumbar spine.

One year following surgery, the adolescents who underwent sleeve gastrectomy lost 34 (+/-13) kg, or 75 (+/-28) pounds, while there was no significant change in weight in the control group.

Compared to the controls, sleeve gastrectomy patients had a significant increase in bone marrow fat and a decrease in bone density in the lumbar spine.

Dr Bella told, “Adolescents who underwent sleeve gastrectomy had bone loss and an increase in bone marrow fat, despite the marked loss of body fat, while weight-loss surgery is successful for weight loss and improving metabolic disorders, it has negative effects on bone.”

According to the study, the researchers concluded that the loss of bone density following sleeve gastrectomy was expected because of greater weight-bearing strengthens bones. In addition to a loss of bone density, other effects of weight-loss surgery include disruption of hormones and nutrients important for bone health.

Hence the awareness of bone health was considered as the main objective to help prevent bone loss in these patients and to make adolescents with obesity.

“Adolescence is the critical time for bone mass accrual, and any process that interferes with bone accrual during this time can have dire consequences later in life,” Dr Bella said.