Thursday, Aug 11, 2022
English News
  • Hyderabad
  • Telangana
  • Andhra Pradesh
  • India
  • World
  • Entertainment
  • Science and Tech
  • Sport
  • Business
  • ...
    • NRI
    • View Point
    • cartoon
    • Columns
    • Reviews
    • Education Today
    • Property
    • Videos
    • Lifestyle
E-Paper
  • NRI
  • View Point
  • cartoon
  • Columns
  • Reviews
  • Education Today
  • Property
  • Videos
  • Lifestyle
Home | Health | New Potential Breast Cancer Drug Identified

New potential breast cancer drug identified

By PTI
Published: Published Date - 02:58 PM, Tue - 13 April 21
New potential breast cancer drug identified
Representational Image The potential drug offers hope for patients whose breast cancer has become resistant to traditional therapies.

Scientists, including an Indian-American researcher, have identified a molecule that can help treat breast cancer, giving hope to patients who have become resistant to traditional therapies.

The first-in-class molecule shuts down oestrogen-sensitive breast cancer in a new way, researchers said.

First-in-class drugs are those that work by a unique mechanism – in this case a molecule that targets a protein on the oestrogen receptor of tumour cells.

The potential drug offers hope for patients whose breast cancer has become resistant to traditional therapies.

“This is a fundamentally different, new class of agents for oestrogen-receptor-positive breast cancer,” said Ganesh Raj, professor at the University of Texas Southwestern (UT Southwestern) Simmons Cancer Center.

“Its unique mechanism of action overcomes the limitations of current therapies,” Raj said.

All breast cancers are tested to determine if they require oestrogen to grow and about 80 per cent are found to be oestrogen-sensitive, researchers said.

These cancers can often be effectively treated with hormone therapy, such as tamoxifen, but as many as a third of these cancers eventually become resistant, they said.

The new compound is a potential highly effective, next-line treatment for these patients, said Raj.

Traditional hormonal drugs, such as tamoxifen, work by attaching to a molecule called the oestrogen receptor in cancer cells, preventing oestrogen from binding to the receptor, a necessary step for cancer cells to multiply.

However, the oestrogen receptor can mutate and change its shape over time so that the treatment drug no longer fits neatly with the receptor. When this happens, the cancer cells start multiplying again.

“There has been intense interest in developing drugs that block the ability of the oestrogen receptor – the prime target in most breast cancers – from interacting with the co-regulator proteins that cause a tumour’s growth,” said David Mangelsdorf, professor at UT Southwestern.

“Blocking such “protein-protein interactions” has been a dream of cancer researchers for decades.

The drug works by blocking other molecules – proteins called co-factors – that also must attach to the oestrogen receptor for cancer cells to multiply.

The new molecule, dubbed ERX-11, mimics a peptide, or protein building block.

  • Follow Us :
  • Tags
  • breast cancer
  • breast cancer drug
  • Cancer
  • Drugs

Related News

  • Former scientist, accomplice making drugs nabbed by Rachakonda cops

    Former scientist, accomplice making drugs nabbed by Rachakonda cops

  • New study: Rainwater is unsafe to consume

    New study: Rainwater is unsafe to consume

  • Health and Tech: The promise of Mistletoe to treat cancer

    Health and Tech: The promise of Mistletoe to treat cancer

  • Cyberabad Police destroy drugs worth Rs 2.5 crore

    Cyberabad Police destroy drugs worth Rs 2.5 crore

  • 7 drugs that may be ‘secretly’ lowering your sex drive

    7 drugs that may be ‘secretly’ lowering your sex drive

  • IIT Madras develops AI tool for personalised cancer diagnosis

    IIT Madras develops AI tool for personalised cancer diagnosis

Latest News

  • Selection list released for admissions into backlog vacancies at TSWREIS

    6 mins ago
  • In a first, Advanced Towed Artillery Gun System to be used on I-Day at Red Fort

    22 mins ago
  • CM KCR extends Raksha Bandhan greetings to people of Telangana

    22 mins ago
  • Horse Racing: Lake Tahoe has the edge in Bengaluru feature

    37 mins ago
  • Hyderabad: Youth from across the world wave the Indian National Flag at the world’s largest meditation center

    41 mins ago
  • The Sensation, Yaletown, Strategist and Quality Warrior shine in trials at Hyderabad Race Course

    45 mins ago
  • FMC Technologies joins Hand in Hand India to celebrate 75th Independence Day

    1 hour ago
  • Hyderabad: Woman falls to death from multi-storied building at Gachibowli

    1 hour ago

company

  • Home
  • About Us
  • Contact Us

business

  • Subscribe

telangana today

  • Telangana
  • Hyderabad
  • Latest News
  • Entertainment
  • World
  • Andhra Pradesh
  • Science & Tech
  • Sport

follow us

© Copyrights 2022 TELANGANA PUBLICATIONS PVT. LTD. All rights reserved. Powered by Veegam